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In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multistep synthesis, most often in organic synthesis. In this type of synthesis several individual pieces of a complex molecule are synthesised in stage one and then in stage two these pieces are combined to form the final product 〔''Organic Synthesis'', 3th Ed. 2010 Michael Smith〕 In linear synthesis the overall yield quickly drops with each reaction step: :A → B → C → D Suppose the yield is 50% for each reaction, the overall yield of D is only 12.5% from A. In a convergent synthesis :A → B (50%) :C → D (50%) :B + D → E (25%) the overall yield of E (25%) looks much better. Convergent synthesis is applied in the synthesis of complex molecules and involve fragment coupling and independent synthesis. Examples: * Convergent synthesis is encountered in dendrimer synthesis 〔Convergent Synthesis of Internally Branched PAMAM Dendrimers Michael Pittelkow, Jrn B. Christensen Org. Lett., 7 (7), 1295 -1298, 2005〕 where branches (with the number of generations preset) are connected to the central core * Proteins of up to 300 amino acids are produced by a convergent approach using chemical ligation. * An example of its use in total synthesis is the final step (photochemical ()cycloaddition) towards the compound ''Biyouyanagin A'':〔''Total Synthesis and Revised Structure of Biyouyanagin'' A K. C. Nicolaou, David Sarlah, and David M. Shaw Angew. Chem. Int. Ed. 2007, 46, 4708 –4711 〕 : ==See also== *divergent synthesis 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Convergent synthesis」の詳細全文を読む スポンサード リンク
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